Colloquium:Evaluation of polygenic risk models using multiple performance measures

maandag 08 oktober 2018 15:45 - 00:45

INVITATION Colloquium Amsterdam UMC research group Community Genetics:

"Evaluation of polygenic risk models using multiple performance measures"- Forike Martens

(PhD Candidate, Department of Clinical Genetics Location VUmc)

The evaluation of polygenic risk models often involves an assessment of different metrics of predictive performance. The area under the receiver operating characteristic curve (AUC) is commonly used for evaluating the improvement of polygenic risk models and increasingly assessed together with the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). What aspects of the predictive performance are reflected by these measures? How are they interpreted and what if their values are discordant?

This presentation covers the findings of a recently published paper by Forike Martens, Ilse Tonk and Cecile Janssens. The aim of the study was to evaluate how authors of polygenic prediction studies described and interpreted multiple performance measures (AUC, NRI, IDI) when used simultaneously in the assessment of improvement in predictive performance. The paper can be found here.

Location: Medical Faculty, Van der Boechorststraat 7, G-123 (First Floor Wing G).

Visitors from outside Amsterdam UMC are also welcome!
Please send an email to Mrs. Wilma IJzerman to register

For more information: Carla van El, T: 020-4448867; E: